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Zymase (Organon): Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Zymase (Organon) - General Information

Protein mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. Contains 3 enzymes, amylase, lipase and a protease (chymotrypsin).

 

Pharmacology of Zymase (Organon)

Used in the treatment of cystic fibrosis or pancreatic dysfunction, pancrelipase helps improve fat digestion in the small intestine. Specifically, the lipase, protease and amylase components break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars. Pancreatic enzymes are used to correct maldigestion, malabsorption and pain associated with pancreatic insufficiency. The major maldigestion/malabsorption problems arise from incomplete fat digestion. Exogenous pancrelipase reduces the amount of nitrogen and fat excreted in the stool.

 

Zymase (Organon) for patients

 

Zymase (Organon) Interactions

 

Zymase (Organon) Contraindications

PANCRECARB (pancrelipase) delayed-release capsules are contraindicated in patients known to be hypersensitive to pork protein. PANCRECARB (pancrelipase) delayed-release capsules are contraindicated in patients under treatment for acute pancreatitis.

 

Additional information about Zymase (Organon)

Zymase (Organon) Indication: For treatment of cystic fibrosis, chronic pancreatitis, pancreatic duct blockage Mechanism Of Action: The lipase, protease and amylase components of pancrelipase break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Pancrelipase Synonyms: 1,4-alpha-D- glucan glucanohydrolase; PA; Pancreatic alpha-amylase precursor Drug Category: Enzyme Replacement Agents Drug Type: Biotech; Approved Other Brand Names containing Pancrelipase: Cotazym (Organon); Ku-Zyme (Koichi); Pancrease (Ortho-McNeil); Ultrase (Axcan Scandipharm); Zymase (Organon); Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Zymase (Organon): Capsule, coated Oral Chemical IUPAC Name: Not Available Chemical Formula: C5850H8902N1606O1739S49 Pancrelipase on Wikipedia: https://en.wikipedia.org/wiki/Pancrelipase Organisms Affected: Humans and other mammals